PhTAD-Substituted Dihydropyrrole Compounds Regulate Apoptotic Cell Death in MCF-7 Cells

Breast cancer is the most common type of amongst women. Apoptosis known as a programmed cell death and this mechanism induces death. Dihydropyrrole compounds contain heterocyclic structure these molecules have many biological effects including functioning antioxidants anticancer molecules. In regard, aim research was to investigate how PhTAD-substituted dihydropyrrole affect expression apoptotic proteins in MCF-7 cells. The levels Bax, Bcl-2, cleaved caspase-3 cells were measured using ELISA method. results revealed that CI, CII, CIII, CV, CVII, CVIII, CXI CXII increased while CXIII CXIV markedly decreased Bax. addition, upregulated Bcl2. Conversely, CIV, downregulated Moreover, CIV Bax/Bcl2 ratio. However, CVIII CIX treatment compared negative control. These findings indicate derivative induced potential regulator